In severe cirrhosis of the liver, how is the action of a drug that is metabolized by the liver typically affected?

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Study for the Mosby's Canadian Practical Nurse Test. Engage with flashcards and multiple choice questions, each with hints and detailed explanations. Prepare thoroughly for your exam!

Multiple Choice

In severe cirrhosis of the liver, how is the action of a drug that is metabolized by the liver typically affected?

Explanation:
When a drug is metabolized by the liver, severe cirrhosis impairs hepatic metabolism and reduces drug clearance. Liver disease slows or diminishes enzyme activity and blood flow to the liver, so the drug is broken down more slowly. This means it stays in the body longer and its effects last longer, increasing the potential for toxicity. So the action is prolonged rather than shortened or blocked.

When a drug is metabolized by the liver, severe cirrhosis impairs hepatic metabolism and reduces drug clearance. Liver disease slows or diminishes enzyme activity and blood flow to the liver, so the drug is broken down more slowly. This means it stays in the body longer and its effects last longer, increasing the potential for toxicity. So the action is prolonged rather than shortened or blocked.

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